Vitamin B6 & Testosterone

Vitamin B6 & Testosterone

Vitamin B6, aka pyridoxine, has a part to play in many bodily functions but is primarily involved in synthesizing protein (1).

It is naturally present in fruits and vegetables, but can also be taken as a supplement.

With regards to its impact on testosterone, there have been no human studies but rodent studies show a positive correlation:

  1. Rats deficient in vitamin B6 had significantly lower testosterone levels (2).
  2. High levels of vitamin B6 reduced estrogen-induced gene expression by 30%. Vitamin B6 deficiency, in-turn, increased estrogen-induced gene expression by 85% (10).

These results are definitely interesting, but without any human trials, it’s hard to say whether this effect carries on to us as well.

In one human study, subjects were put on a stationary bike whereby they pushed to 80% of their heart rate.

Subjects given 600mg of pyridoxine noted greater increases in growth hormone and lower prolactin levels compared to placebo (11).

So vitamin B6 may impact testosterone indirectly:

Both higher GH and lower prolactin may translate to higher T.

These studies are definitely not conclusive and more trials are needed to confirm these results. Nonetheless, vitamin B6 does aid overall health and the addition of it in TestoFuel can’t hurt.


David Becker, RN, CCRN
David Becker, RN, CCRN Mr. Becker is a father, husband, and CCRN in Trauma ICU. You can read his inspiring comeback story From 412ng/dl To 923ng/dl In 6 Months - Without TRT. Feel free to send David a message here.